Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19코로나19 중증도에 따라 항체 표적 SARS-CoV-2 에피토프 레퍼토리 달라Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] antibodies antibody Antigen association Asymptomatic asymptomatic individual asymptomatic infection Betacoronavirus betacoronavirus Community convalescent correlated COVID-19 COVID-19 severity develop diagnosed diagnostics disease severity domains Epitopes Evidence evidence of finding FIVE five groups HKU1 Hospitalization IgG IgGs Immunity immunogenic immunogenic peptide individual Infection less MERS-CoV nucleocapsid protein Nucleocapsid proteins OC43 participant pathogenic pathogenic mechanisms peptide peptide array peptides pilot study predicted Protein RBDs reaction Receptor binding domain Region repertoire SARS-CoV RBD SARS-CoV RBDs SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted Seroprevalence seroprevalence. severity severity of COVID-19 symptomatic symptomatic COVID-19 symptomatic infection therapeutic therapeutic antibodies Vaccines Viral with COVID-19 without symptoms [DOI] 10.1080/21505594.2022.2073025 PMC 바로가기 [Article Type] Article
Clinical utility of circulating calprotectin to assist prediction and monitoring of COVID-19 severity: An Italian studyArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] 바이오마커, [키워드] Administered Admission assist Biomarker calprotectin Care chemiluminescent immunoassay circulating Circulating calprotectin clinical Cohort collected Concentration controls correlation COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease severity evaluate healthy individual ICU intubation Italian study median Patient positive airway pressure Respiratory Support risk risk assessment. Sample serological serum severity of COVID-19 Severity of disease significantly higher tested utility were used [DOI] 10.1002/jmv.28056 PMC 바로가기
The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6Article Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] antibodies antibody Antibody escape mutation binding binding interaction claimed COVID-19 human population IMPROVE molecular Mutation mutations N501Y Neutralizing antibodies neutralizing antibody pathogen Potential treatment predicted previous study Receptor binding domain responsible resulting S-RBD SARS-CoV-2 severity of COVID-19 the SARS-CoV-2 therapeutic [DOI] 10.1038/s41598-022-23482-5 PMC 바로가기
Implications of COVID-19 infection on patients with uveitis under biologic treatmentArticle Published on 2022-11-012022-11-15 Journal: The British journal of ophthalmology [Category] 진단, [키워드] biologic biologic agent carrier COVID-19 COVID-19 infection COVID-19 pandemic COVID-19-related symptom Diagnosis disease Follow-up immunology incidence Infection infection. infliximab nine outcome Patient positive positive COVID-19 Prospective Study severity of COVID-19 silent tested the patient therapy treated Treatment Uveitis [DOI] 10.1136/bjophthalmol-2020-318577 PMC 바로가기
Covid-MANet: Multi-task attention network for explainable diagnosis and severity assessment of COVID-19 from CXR imagesResearch article Published on 2022-11-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 진단, 치료기술, [키워드] Accuracy approach approach assigned automated Bacterial chest X-ray CNN conducted COVID-19 COVID-19 case COVID-19 cases COVID-19 diagnosis COVID-19 disease COVID-19 infection Critical CXR dataset deep learning develop Diagnosis disease early diagnosis eight experiment Explainable AI False negative Final first stage Health highlight IMPROVE Infection Infection Segmentation initial Interpretation lung Lung segmentation Lungs measure Mild moderate outbreak outperform Pneumonia predicted proportion quantification radiological examination reduced Region reported Research research finding RT-PCR test scoring system sensitivity sensitivity analysis severity severity of COVID-19 Stage Support transfer learning Tuberculosis Viral pneumonia with COVID-19 [DOI] 10.1016/j.patcog.2022.108826 [Article Type] Research article
Does vitamin D supplementation reduce COVID-19 severity?: a systematic reviewArticle Published on 2022-10-252022-11-16 Journal: QJM: An International Journal of Medicine [Category] meta-analysis, [키워드] Covid patients COVID-19 COVID-19 severity effective Efficacy eligible Evidence Google heterogeneity heterogeneous hospitalized COVID-19 initial screening intensive care lack mechanical ventilation Meta-analysis morbidity and mortality Mortality overlapping presenting qualitative analysis ranged reduce reducing required risk robust Safe screened selected Seven severity of COVID-19 systematic review systematic reviews therapy Trial Vitamin D supplementation were assessed [DOI] 10.1093/qjmed/hcac040 PMC 바로가기
A Mendelian randomization study of genetic predisposition to autoimmune diseases and COVID-19Article Published on 2022-10-212022-11-16 Journal: Scientific Reports [Category] 변종, [키워드] Analysis Antigen association Autoimmune disease Autoimmune diseases biliary cirrhosis concern coronavirus disease COVID-19 COVID-19 susceptibility Diabetes Mellitus disease examined Genetic predisposition Genetic variant Genome-wide association studies Genome-wide association study hospitalized COVID-19 immune response Infection juvenile idiopathic arthritis leukocyte mendelian randomization Mendelian randomization analysis multiple sclerosis performed rheumatoid arthritis severe COVID-19 severity severity of COVID-19 similarities susceptibility systemic lupus erythematosus with COVID-19 [DOI] 10.1038/s41598-022-22711-1 PMC 바로가기
Environmental Impacts on COVID-19: Mechanisms of Increased SusceptibilityArticle Published on 2022-10-212022-11-16 Journal: Annals of Global Health [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition age Air pollution antioxidant benefit boost caused changes in children clinical symptom combating coronavirus COVID COVID 19 COVID-19 COVID-19 susceptibility death described disease Diseases Environment Epidemiology exposure to free radical Health host immunity host susceptibility Impact Increased induce Inflammatory cytokine storm inhibit Initially International involved knowledge less mechanism morbidity and mortality outcomes oxidative stress pediatric Preliminary data reduce respiratory tract respiratory viral infections respiratory viral infections. SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severity severity of COVID-19 shown susceptibility susceptible the disease Vaccine variant viral genome viral infections viral pathogenicity while [DOI] 10.5334/aogh.3907 PMC 바로가기
Delayed encephalopathy after COVID-19: A case series of six patientsArticle Published on 2022-10-212022-11-15 Journal: Medicine [Category] 진단, [키워드] absence accompanied acute respiratory syndrome Administered age autoantibody case sery cerebrospinal fluid characterized Computed tomography contribute coronavirus coronavirus disease COVID-19 CSF Delayed demonstrated disturbance of consciousness Duration dysfunction electroencephalogram elevated Encephalopathy evaluated female Hospitalization Immunoglobulin Immunotherapy interleukin-6 lacunar infarction magnetic resonance imaging males moderate MOST neurological Neurological deficit occur Pathogenesis Patient patients polymerase chain protein level pulse ranged remained Repeat resolved reverse transcription serum severity of COVID-19 Symptom Treatment with COVID-19 worsening [DOI] 10.1097/MD.0000000000031029 PMC 바로가기